| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764644 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠We investigated the effect 6 Gy of WBI on the autophagic machinery of normal mouse lung. ⺠Irradiation induces dysfunction of the autophagic machinery in normal lung, characterized by decreased transcription of the LC3A/Beclin-1 mRNA and accumulation of the LC3A, and p62 proteins. ⺠The membrane bound LC3A-II protein levels increased in the cytosolic fraction (not in the pellet), contrasting the patterns noted after starvation-induced autophagy. ⺠Administration of amifostine, reversed all the LC3A and p62 findings, suggesting protection of the normal autophagic function.
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Authors
Christos E. Zois, Alexandra Giatromanolaki, Heikki Kainulainen, Sotirios Botaitis, Sira Torvinen, Constantinos Simopoulos, Alexandros Kortsaris, Efthimios Sivridis, Michael I. Koukourakis,