| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764654 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠Activity of glutamyl-tRNA synthetase is lost by oxidation with H2O2 and hemin. ⺠Cysteines from a Zn2+ binding site are the targets of oxidation. ⺠Zn2+ is released by oxidation, but activity is lost before Zn2+ is released. ⺠ATP and tRNA protect the cysteines from oxidation. ⺠Redox status of GluRS1 might regulate protein and tetrapyrrole biosynthesis.
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Authors
Assaf Katz, Rajat Banerjee, Merly de Armas, Michael Ibba, Omar Orellana,