Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10764671 | Biochemical and Biophysical Research Communications | 2010 | 7 Pages |
Abstract
⺠Targeting glutamine metabolism sensitized melanoma to enhanced killing by TRAIL. ⺠However, normal cells were not killed by the same treatment. ⺠AOA plus TRAIL enhanced killing of melanoma mediated by caspases. ⺠AOA plus TRAIL reduced pro-survival proteins (Bcl2, Mcl-1). ⺠AOA plus TRAIL increased pro death molecule Noxa.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
J.-Z. Qin, H. Xin, B.J. Nickoloff,