Article ID Journal Published Year Pages File Type
10764671 Biochemical and Biophysical Research Communications 2010 7 Pages PDF
Abstract
► Targeting glutamine metabolism sensitized melanoma to enhanced killing by TRAIL. ► However, normal cells were not killed by the same treatment. ► AOA plus TRAIL enhanced killing of melanoma mediated by caspases. ► AOA plus TRAIL reduced pro-survival proteins (Bcl2, Mcl-1). ► AOA plus TRAIL increased pro death molecule Noxa.
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