Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10764768 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠CD38-deficient MEFs were more resistant to oxidative stress than WT MEFs. ⺠CD38-knockout appeared to block the production of ROS and elevation of Nox1 mRNA level after hypoxia/reoxygenation. ⺠CD38-knockout blocked the burst of [Ca2+]i induced by oxidative stress in MEFs. ⺠The transcriptional activity of Nox1 may be positively influenced by intracellular [Ca2+]. ⺠The lower expression of Nox1 mRNA in CD38-/- MEFs during oxidative stress might be contributed by a lower [Ca2+]i.
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Authors
Yan Ge, Wei Jiang, Lu Gan, Lijun Wang, Changyan Sun, Peiyan Ni, Yin Liu, Sisi Wu, Lunda Gu, Wei Zheng, Frances E. Lund, Hong-Bo Xin,