The p76Rb and p100Rb truncated forms of the Rb protein exert antagonistic roles on cell death regulation in human cell lines

► p76Rb and p100Rb have distinct roles from full-length Rb in cell death regulation. ► p76Rb triggers cell death in HEK293T, HT1080, SAOS-2, TC7 and HT29 cell lines. ► p100Rb can inhibit cell death in HT1080 and SAOS-2 cell lines. ► p76Rb regulates cell death by inducing the mitochondrial pathway of apoptosis. ► p100Rb decreases p53 and caspase activities in HT1080 cells.