| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764792 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠Identification of a novel effect of lithium on the expression of TCF7L2 RNA isoforms and protein variants. ⺠The extent of lithium-induced TCF7L2 form switch mirrors cell responsiveness to Wnt/β-catenin signaling. ⺠Demonstration that lithium has dual GSK3β-dependent and -independent effects on TCF7L2 expression. ⺠Demonstration that TCF7L2 expression is repressed by the transcriptionally active TCF7L2E form. ⺠Evidence for a lithium-induced de-repression mechanism of TCF7L2 expression via TCF7L2 variant switch.
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Authors
Ian Struewing, Tania Boyechko, Corey Barnett, Marcy Beildeck, Stephen W. Byers, Catherine D. Mao,