| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764842 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.
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Authors
Marie Potier, Truong An Tran, Aurelie Chantome, Alban Girault, Virginie Joulin, Philippe Bougnoux, Christophe Vandier, Fabrice Pierre,