| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764922 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
âºInsulin receptor antagonist S961 causes hyperglycemia, hyperinsulinemia and insulin resistance in rats. âºPeroxysome-proliferator-activated-receptor-gamma agonist pioglitazone improves S961 induced hyperglycemia and glucose intolerance. âºLong term treatment with insulin receptor antagonist S961 results in the decreased adiposity and hepatic glycogen content. âºImprovement in the hyperglycemia and glucose intolerance by pioglitazone clearly demonstrates that S961 treated rats can be successfully used to screen the novel therapeutic interventions having potential to improve glucose disposal through receptor independent mechanisms.
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Authors
Ajit Vikram, Gopabandhu Jena,