| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764958 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠Nifedipine inhibited the AGE-induced up-regulation of RAGE mRNA levels in tubular cells, which was prevented by GW9662, an inhibitor of peroxisome proliferator-activated receptor-γ. ⺠GW9662 treatment alone increased RAGE mRNA levels in tubular cells. ⺠Nifedipine inhibited the AGE-induced reactive oxygen species generation, NF-κB activation and increases in intercellular adhesion molecule-1 and transforming growth factor-β gene expression in tubular cells, all of which were blocked by GW9662.
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Authors
Takanori Matsui, Sho-ichi Yamagishi, Masayoshi Takeuchi, Seiji Ueda, Kei Fukami, Seiya Okuda,