| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764982 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
The aim was to analyze the mechanism of leptin-induced activity of telomerase in MCF-7 breast cancer cells. We found that leptin activated telomerase in a dose-dependent manner; leptin upregulated the expression of Human Telomerase Reverse Transcriptase (hTERT) at mRNA and protein levels; blockade of signal transducer and activator of transcription 3 (STAT3) phosphorylation significantly counteracted leptin-induced hTERT transcription and protein expression; chromatin immunoprecipitation analysis showed that leptin enhanced the binding of STAT3 to the hTERT promoter. This study uncovers a new mechanism of the proliferative effect of leptin on breast cancer cells and provides a new explanation of obesity-related breast cancer.
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Authors
He Ren, Tiansuo Zhao, Xiuchao Wang, Chuntao Gao, Jian Wang, Ming Yu, Jihui Hao,