Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10765054 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
Tetraphenylethylene (TPE) derivatives have strong fluorescence in aggregated state. We designed and synthesized a tetraphenylethylene derivative bearing alkyne groups which were used for combination by click chemistry. The new TPE compound bearing alkyne groups was used to synthesize fluorescence oligosaccharide probes which have lactosyl and 6â²-sialyllactosyl moieties as ligands. We found that the TPE compounds bearing lactosyl and 6â²-sialyllactosyl moieties were useful for detection of RCA120 and SSA lectins, respectively. Moreover, we have shown that TPE-based fluorescent oligosaccharide probe bearing 6â²-sialyllactose moiety can be utilized as a “turn-on” fluorescent sensor for detection of influenza virus.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Tomohisa Kato, Atsushi Kawaguchi, Kyosuke Nagata, Kenichi Hatanaka,