Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10765146 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
The gene of (all-E) geranylfarnesyl diphosphate synthase that is responsible for the biosynthesis of methanophenazine, an electron carrier utilized for methanogenesis, was cloned from a methanogenic archaeon Methanosarcina mazei Gö1. The properties of the recombinant enzyme and the results of phylogenetic analysis suggest that the enzyme is closely related to (all-E) prenyl diphosphate synthases that are responsible for the biosynthesis of respiratory quinones, rather than to the enzymes involved in the biosynthesis of archaeal membrane lipids, including (all-E) geranylfarnesyl diphosphate synthase from a thermophilic archaeon.
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Authors
Takuya Ogawa, Tohru Yoshimura, Hisashi Hemmi,