Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10765262 | Biochemical and Biophysical Research Communications | 2010 | 7 Pages |
Abstract
We conclude that platelet activation triggers FXII-mediated contact activation on the surface and in the vicinity of activated platelets. This leads specifically to generation of FXIIa-AT and FXIa-AT complexes, and contributes to clot formation. Activated platelets may thereby constitute an intravascular locus for contact activation, which may explain the recently reported importance of FXII in thrombus formation.
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Authors
Jennie Bäck, Javier Sanchez, Graciela Elgue, Kristina Nilsson Ekdahl, Bo Nilsson,