| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10766498 | Biochemical and Biophysical Research Communications | 2009 | 5 Pages |
Abstract
In this study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane studies, a fluidizing effect was seen also in the endosomal membranes during CPV infection implying an important functional role of the fluidization in the endocytic entry of the virus.
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Authors
Kirsi Pakkanen, Sanna Kirjavainen, Anna R. Mäkelä, Nina Rintanen, Christian Oker-Blom, Tuula O. Jalonen, Matti Vuento,