Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10766576 | Biochemical and Biophysical Research Communications | 2008 | 5 Pages |
Abstract
Atherosclerosis is a chronic inflammatory disease of the arteries resulting from interactions between lipids, monocytes, and arterial wall cells. The effects of resveratrol supplements (RV, 0.02% and 0.06% each, w/w) with regard to the modulation of lipid profiles, cholesterol synthesis, and anti-atherogenesis were examined in apo E-deficient (apo Eâ/â) mice fed a normal diet. The concentration of total-cholesterol (total-C) and LDL-cholesterol (LDL-C) in plasma was significantly lower in the resveratrol-supplemented groups compare to the control group over the entire experimental period. The plasma HDL-C concentration was significantly elevated, and the ratio of HDL-C/total-C was significantly higher in the CF and RV groups than in the control group. Plasma paraoxonase (PON) activity was significantly higher in the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity was significantly lower in the clofibrate and resveratrol groups than in the control group. Resveratrol supplements attenuated the presence of atherosclerotic lesions and periarterial fat deposition in the apo Eâ/â mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was diminished in the resveratrol-supplemented apo Eâ/â mice. These results provide new insight into the anti-atherogenic and hypocholesterolemic properties of resveratrol in apo Eâ/â mice that were fed a normal diet.
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Authors
Gyeong-Min Do, Eun-Young Kwon, Hye-Jin Kim, Seon-Min Jeon, Tae-Youl Ha, Taesun Park, Myung-Sook Choi,