Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10766944 | Biochemical and Biophysical Research Communications | 2007 | 5 Pages |
Abstract
Interleukin 6 (IL6)-type cytokines are major regulators of inflammation and thereby contribute to the neuropathology and pathophysiology associated with inflammation of the central nervous system (CNS). Furthermore, astrocyte development which is a key process in the development of the CNS is also controlled by cytokines of the IL6-family. Interleukin 27 (IL27) is a recently identified member of this family and has been implicated in the inhibition of TH17 T-cell-responses. Here we show that IL27 and the HHV8 encoded viral IL6 (vIL6) induce C6 glioma cells to differentiate into an astrocyte-like state. Cytokine stimulation led to STAT-factor phosphorylation and consequently to protein expression of the astrocyte marker glial fibrillary acidic protein (GFAP). These data could be confirmed by GFAP-immunostaining of stimulated cells. Taken together, IL27 and vIL6 can be considered as new astrocyte-inducing cytokines of the brain.
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Authors
Manuel Koch, Ulrike May, Stefanie Kuhns, Hauke Drechsler, Nina Adam, Kirsten Hattermann, Stefan Wirtz, Stefan Rose-John, Jürgen Scheller,