Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10767066 | Biochemical and Biophysical Research Communications | 2007 | 6 Pages |
Abstract
Pigment epithelium-derived factor (PEDF or SERPINF1), a neuroprotective and anti-angiogenic factor, may play an important role in the pathogenesis of diabetic retinopathy (DR). In 416 patients with type 2 diabetes, four polymorphisms in the PEDF SNPs were identified, rs12150053 and rs12948385 in the promoter region, rs9913583 in the 5â²-untranslated region, and rs1136287 (Met72Thr) in exon 3. Based on case-control studies, rs12150053 and rs12948385, but not rs9913583 and rs1136287, were significantly associated with DR. A logistic regression analysis revealed that the TC or CC genotype of rs12150053 was a significant risk factor for DR (odds ratio 2.40, p = 0.0004). The GA or AA genotype of rs12948385 was also a significant risk factor for DR. In addition, a significant interaction between the vascular endothelial growth factor (VEGF) and PEDF SNPs in the susceptibility to DR was found. These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of DR.
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Authors
Hiroyuki Iizuka, Takuya Awata, Masataka Osaki, Tamotsu Neda, Susumu Kurihara, Kiyoaki Inoue, Kouichi Inukai, Sho Kabasawa, Keisuke Mori, Shin Yoneya, Shigehiro Katayama,