Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10767354 | Biochemical and Biophysical Research Communications | 2007 | 7 Pages |
Abstract
During cell cycle progression and division, how cells coordinate mitochondrial biogenesis, distribution, and partitions remains to be clarified. Here, we show that mitochondrial mass and mitochondrial membrane potential increased from early G1 to G1/S and further gradually elevated to mitotic phase, indicating that mitochondrial biogenesis begins from early G1 phase. In addition, mitochondrial DNA contents appeared to increase from G1/S to G2 phase during which a slight but consistent increase of NRF-1 level was observed. However, other transcriptional factors regulating mitochondrial biogenesis, mtTFA and PRC, were not changed. During interphase, heterogeneous mitochondrial population with different morphology and sizes were observed but reorganized into relatively homogeneous population of mitotic cells. Moreover, microtubule and dynein complex, p150Glued and dynein intermediate chain, strongly associate with mitochondria during interphase but dissociated from them during mitosis. Taken together, our results suggest that mitochondrial biogenesis and dynamics are tightly regulated during cell cycle progression.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Seungmin Lee, Sujeong Kim, Xuejun Sun, Jae-Ho Lee, Hyeseong Cho,