Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10767369 | Biochemical and Biophysical Research Communications | 2007 | 7 Pages |
Abstract
The learning and memory impairment of presenilin 2 transgenic mice was mentioned previously. In this study, exposing the presenilin 2 transfected PC12 cells to the 50 μM Aβ25-35, 30 mM l-glutamate and 50 μM H2O2 resulted in significant increase 8-oxodG and p53 levels of the cells expressing the mutant gene. The increase was also found in the mutant presenilin 2 transgenic mice brains age-dependently in comparison to that in the wild-type presenilin 2-transgenic mice and non-transgenic ones. These findings indicated that mutant presenilin 2 clearly increases oxidative stress and p53 expression, which could be implicated in promoting mutant presenilin 2-induced neurodegeneration in Alzheimer's disease, and the influence of mutant presenilin 2 in Alzheimer's disease may be brain regional and age related effects.
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Authors
Hong Nga Nguyen, Moon Soon Lee, Dae Youn Hwang, Young Kyu Kim, Do Young Yoon, Jae Woong Lee, Yeo Pyo Yun, Myung Koo Lee, Ki Wan Oh, Jin Tae Hong,