| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10767493 | Biochemical and Biophysical Research Communications | 2007 | 6 Pages |
Abstract
GDF15 is a transcriptional target gene for p53 and its family members, p63 and p73. Its promoter region contains two p53-type response elements, RE1 and RE2, and RE2 confers p53-specific transactivation. RE2 contains several mismatches from the canonical p53 response element (RRRCWWGYYY). Two mismatches in the RRR span and T base of the RE2 core sequence in the most 3â² quarter-site are critical for inhibiting the binding affinity to p63 and p73 and corresponding promoter activity. Our results strongly suggest that differential DNA-binding affinities between p53 family member proteins act, at least in part, to confer specific target gene activation.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Motonobu Osada, Hannah Lui Park, Min Joo Park, Jun-Wei Liu, Guojun Wu, Barry Trink, David Sidransky,