| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10768010 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
It is proposed that the hydronium ion, H3O+, binds to the E1 conformation of the α-subunit of gastric proton pump. The H3O+ binding cavities are characterized parametrically based on valence, sequence, geometry, and size considerations from comparative modeling. The cavities have scope for accommodating monovalent cations of different ionic radii. The H3O+ transport is proposed to be aided by arenes which are arranged regularly along the pump starting from N-domain through the transmembrane region. Step-by-step structural changes accompanying H3O+ occlusion are studied in detail. The observations corroborate well with earlier experimental studies.
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Authors
Mukesh Chourasia, G. Madhavi Sastry, G. Narahari Sastry,