Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10768088 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-β plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-α4 can be induced independently of IFN-β. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-β.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Christofer V. Samuelsson, Stefan Lienenklaus, Peter P. Müller, Rainer Zawatzky, Hansjörg Hauser, Siegfried Weiss,