| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10768107 | Biochemical and Biophysical Research Communications | 2005 | 9 Pages |
Abstract
Activation of cyclooxygenase catalysis in prostaglandin H synthase-1 and -2 by peroxide-dependent formation of a tyrosyl radical is emerging as an important part of regulating cellular production of bioactive prostanoids. This review discusses the mechanism of tyrosyl radical formation and the influence of peroxide, fatty acid, peroxidase cosubstrate, and protein structure on the activation process and cyclooxygenase catalysis.
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Authors
Richard J. Kulmacz,