| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10768226 | Biochemical and Biophysical Research Communications | 2005 | 7 Pages |
Abstract
Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.
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Authors
Kiichi Hirota, Gregg L. Semenza,