Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10768242 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
The contribution of plasma membrane-associated glucocorticoid receptor (GR) to transcriptional signaling is unclear. We observed GR in low-density detergent-resistant membrane (DRM) rafts derived from human hepatoma Hep3B cells in complexes with caveolin-1, HSP90, and STAT3. In transient transfection assays, GR-stimulated transcriptional signaling was reversibly inhibited by membrane-raft disrupters filipin III and progesterone. These data provide clear evidence for a functional contribution of DRM-associated GR to transcriptional signaling.
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Authors
Sudhir Jain, Yanna Li, Ashok Kumar, Pravin B. Sehgal,