| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10768317 | Biochemical and Biophysical Research Communications | 2005 | 4 Pages |
Abstract
MicroRNAs (miRNAs), 18-25Â nt single-stranded RNAs, act as regulators in fine-tuning gene function. The absence of miRNAs is not life-threatening in early embryonic development of Dicer-knockout zebrafish and mice, which may account for genetic expression of various traits as a result of miRNA complexity in higher animals during natural evolution. The Pol-II-mediated intronic miRNA is a useful tool to validate the function of computer-predicated miRNAs in zebrafish and mice.
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Authors
Shao-Yao Ying, Shi-Lung Lin,