Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10768597 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
Genomic alternations, including dosage and allelic imbalance, constitute a major basis of neoplastic and other genetic disorders. Using oligonucleotide genotyping microarrays, here we report the development and usage of an algorithm, called genome imbalance map (GIM) algorithm, for allelic as well as total gene dosage analysis. Using the GIM algorithm, global genome imbalance status at over 100,000 loci was simultaneously analyzed with unprecedented accuracy and allelic discrimination.
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Authors
Shumpei Ishikawa, Daisuke Komura, Shingo Tsuji, Kunihiro Nishimura, Shogo Yamamoto, Binaya Panda, Jing Huang, Masashi Fukayama, Keith W. Jones, Hiroyuki Aburatani,