Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10768725 | Biochemical and Biophysical Research Communications | 2005 | 5 Pages |
Abstract
Cell-penetrating peptide (CPP) was linked to insulin to form insulin-CPP hybrids. The intestinal absorption efficiency of CPP hybridized insulin was 6-8 times increased compared to normal insulin as tested on Caco-2 cell monolayer, a widely used in vitro model for intestinal absorption. Insulin-CPP hybrid transportation seemed to be through an active and transcytosis-like mechanism. Importantly, insulin in hybrids kept intact after they passed through the Caco-2 cell monolayer. This study provides a new clue for oral insulin development.
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Authors
Jun F. Liang, Victor C. Yang,