Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10769027 | Biochemical and Biophysical Research Communications | 2005 | 4 Pages |
Abstract
Adiponectin, an adipocyte-derived hormone, reportedly suppresses the production of TNF-α and IL-6 by LPS-stimulated human or porcine macrophages, and the phagocytosis of microbeads by human macrophages. In this study, we used a high molecular weight form of adiponectin purified from human plasma to examine its effects on the phagocytosis of late apoptotic cells by human macrophages and the subsequent IL-8 production. Adiponectin suppressed both the phagocytosis of apoptotic cells and the IL-8 production. In contrast, adiponectin augmented both the phagocytosis of apoptotic cells and the IL-8 production in the presence of LPS. These results suggest that adiponectin is not an anti-inflammatory hormone but rather a dual modulator of innate responses.
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Authors
Shinji Saijo, Kisaburo Nagata, Yasuko Nakano, Takashi Tobe, Yoshiro Kobayashi,