Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10769862 | Biochemical and Biophysical Research Communications | 2005 | 5 Pages |
Abstract
We evaluated the effects of extremely low frequency magnetic field (ELFMF) on glucose-stimulated insulin secretion from HIT-T15 cells and investigated the mechanisms of these effects. We demonstrated that exposure to ELFMF at 5Â mT decreased glucose-stimulated insulin secretion by preventing the increases in cellular adenosine 5â²-triphosphate/adenosine 5â²-diphosphate, membrane depolarization, and cytosolic free calcium ion concentration. The glucose-induced upregulation of insulin mRNA expression was also attenuated by exposure to ELFMF, although cell viability was not affected. These findings demonstrate the potential of exposure to ELFMF for clinical use as a novel inhibitory method of insulin secretion.
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Authors
Tomonori Sakurai, Shin Koyama, Yoshiki Komatsubara, Wang Jin, Junji Miyakoshi,