Article ID Journal Published Year Pages File Type
10769862 Biochemical and Biophysical Research Communications 2005 5 Pages PDF
Abstract
We evaluated the effects of extremely low frequency magnetic field (ELFMF) on glucose-stimulated insulin secretion from HIT-T15 cells and investigated the mechanisms of these effects. We demonstrated that exposure to ELFMF at 5 mT decreased glucose-stimulated insulin secretion by preventing the increases in cellular adenosine 5′-triphosphate/adenosine 5′-diphosphate, membrane depolarization, and cytosolic free calcium ion concentration. The glucose-induced upregulation of insulin mRNA expression was also attenuated by exposure to ELFMF, although cell viability was not affected. These findings demonstrate the potential of exposure to ELFMF for clinical use as a novel inhibitory method of insulin secretion.
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