| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10770036 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
The blood-brain barrier (BBB) is a biological unit composed of capillary endothelial cells and astrocytes. Here we examined the effects of various types of advanced glycation end-products (AGEs) on astrocytes and BBB-forming endothelial cells. While no type of AGE we examined changed the permeability of endothelial sheets, glyceraldehyde-derived AGE induced VEGF expression most significantly in astrocytes. The expression of glial cell line-derived neurotrophic factor (GDNF), which reduces the vascular permeability, was decreased in the astrocytes by treatment with glyceraldehyde-derived AGE. These results indicate that glyceraldehyde-derived AGE is the biologically active substance for astrocytes by regulating the VEGF and GDNF expression, which is causally contributing to an increase in the permeability of the BBB.
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Authors
Hideaki Miyajima, Makoto Osanai, Hideki Chiba, Nami Nishikiori, Takashi Kojima, Kenji Ohtsuka, Norimasa Sawada,