Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10770105 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.
Keywords
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Authors
Ai-Guo Wang, Sang-Beom Seo, Hyung-Bae Moon, Hye-Jun Shin, Dong Hoon Kim, Jin-Man Kim, Tae-Hoon Lee, Ho Jeong Kwon, Dae-Yeul Yu, Dong-Seok Lee,