Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10770814 | Biochemical and Biophysical Research Communications | 2005 | 5 Pages |
Abstract
A recently described triple-transgenic mouse model (3ÃTg, PS1M146V, APPSwe, and tauP301L) develops a neuropathology similar to the brains of Alzheimer's disease patients including progressive deposits of plaques and tangles [Neuron 39 (2003) 409]. These mice also show age-related deficits in hippocampal synaptic plasticity that occurs before the development of plaques and tangles. Here we report unchanged synaptic vesicle recycling, as measured by FM1-43 release, in the hippocampal neurons of the 3ÃTg mice. Expression levels of presynaptic protein synaptophysin and of proteins involved in synaptic vesicle recycling including AP180, dynamin I, and synaptotagmin I also remain unaffected. These data suggest that the synaptic deficits observed in the 3ÃTg neurons may not arise from the preserved synaptic vesicle recycling.
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Authors
Pamela J. Yao, Ittai Bushlin, Katsutoshi Furukawa,