| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10771030 | Biochemical and Biophysical Research Communications | 2005 | 6 Pages |
Abstract
A gramicidin A derivative with a polyether linkage between both ethanolamine termini was synthesized and its ion channel properties were studied. The compound showed a duplication in the state of conductance for alkali cations in thick DOPC bilayer membranes, which is interpreted as the occurrence of twin-channels. In thinner DMPC membranes mono-channels were dominant. The influence of hydrophobic coupling on the mono channel/twin channel equilibrium is discussed.
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Authors
Lo'ay Al-Momani, Philipp ReiÃ, Ulrich Koert,