| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10771090 | Biochemical and Biophysical Research Communications | 2005 | 8 Pages |
Abstract
In this study, we determined the role of PDGF-D, a new member of the PDGF family, in a rat model of balloon injured artery made with a 2F catheter in Sprague-Dawley male rats. PDGF-D expression was studied in the injured and control segments of abdominal aorta. The function of PDGF-D was evaluated in rat vascular smooth muscle cells stably transfected with PDGF-D gene. We found that in normal abdominal aorta, PDGF-D was highly expressed in adventia, moderate in endothelia, and unidentified in media. Stable transfection of PDGF-D gene into vascular smooth muscle cells increased the cell migration by 2.2-fold, and the proliferation by 2.3-fold, respectively, and MMP-2 production and activity as well. These results support the fact that PDGF-D is involved in the formation of neointimal hyperplasia induced by balloon catheter injury and may serve as a target in preventing vascular restenosis after coronary angioplasty.
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Authors
Jingzhou Chen, Yu Han, Chunxia Lin, Yisong Zhen, Xiaodong Song, Siyong Teng, Chen Chen, Yu Chen, Yinhui Zhang, Rutai Hui,