| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10771629 | Biochemical and Biophysical Research Communications | 2005 | 4 Pages |
Abstract
Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and μ-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain activity, but remained fully capable of inhibiting the HIV-1 protease. Any calpain-related effects of ritonavir in cells must, therefore, arise by a mechanism other than direct inhibition of calpains.
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Authors
Dominic Cuerrier, Zilin Nie, Andrew D. Badley, Peter L. Davies,