Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10771710 | Biochemical and Biophysical Research Communications | 2005 | 5 Pages |
Abstract
While agents targeting estrogen receptors are most effective in adjuvant therapy for human breast cancers expressing estrogen receptors after surgery, breast cancers lacking estrogen receptor are clinically serious, because they are highly malignant and exhibit resistance to the usual anti-cancer drugs, including estrogen receptor-antagonists and DNA breaking agents. Here, we found that MX-1, a human breast cancer cell line lacking estrogen receptors, exhibited higher AP-1 activity and expressed higher levels of c-Jun, c-Fos, and Fra-1 when compared with conventional estrogen receptor-positive human breast cancer cell lines. The prenylphenol antibiotic ascochlorin suppressed the AP-1 activity of MX-1 cells, and selectively killed MX-1 cells, partly due to induction of apoptosis. Our results suggest that AP-1 is an effective clinical target molecule for the treatment of estrogen receptor-negative human breast cancer.
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Authors
Koichi Sakaguchi, Hiroo Nakajima, Naruhiko Mizuta, Chiharu Furukawa, Satoshi Ozawa, Kunio Ando, Young-Chae Chang, Hisakazu Yamagishi, Junji Magae,