Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10772031 | Biochemical and Biophysical Research Communications | 2005 | 8 Pages |
Abstract
The estrogenic activity of several intermediary plant compounds has raised concern about possible risks of unwanted interference with endocrine regulation, but on the other hand there are potential medical benefits, in particular in treatment of menopausal symptoms or cancer. In the present study, we compare the estrogenic effects of phytoestrogens naringenin, 8-prenylnaringenin, 6-(1,1-dimethylallyl)naringenin, and the synthetic 4â²-acetyl-7-prenyloxynaringenin. Two mammalian in vitro systems and a fish in vivo system were used to study the estrogenic properties with reference to genistein, 17-β-estradiol or ethynylestradiol. Strong differences were observed between the mammalian in vitro and the fish in vivo test system. In the medaka sex reversal/vtg gene expression assay no estrogenic effects of the naringenin-type flavonoids were observed, while mammalian in vitro systems showed a similar and graded response to the test compounds.
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Authors
Oliver Zierau, Juliane Hamann, Sandra Tischer, Pia Schwab, Peter Metz, Günter Vollmer, Herwig O. Gutzeit, Stefan Scholz,