Article ID Journal Published Year Pages File Type
10796533 Biochimica et Biophysica Acta (BBA) - Biomembranes 2016 19 Pages PDF
Abstract
Understanding the mode of action of antibiotics is becoming more and more important in the time that microorganisms start to develop resistance. One very well validated target of several classes of antibiotics is the peptidoglycan precursor lipid II. In this review different classes of lipid II targeting antibiotics will be discussed in detail, including the lantibiotics, human invertebrate defensins and the recently discovered teixobactin. By hitting bacteria where it hurts, at the level of lipid II, we expect to be able to develop efficient antibacterial agents in the future. This article is part of a Special Issue entitled: Antimicrobial peptides edited by Karl Lohner and Kai Hilpert.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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