| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797031 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 9 Pages |
Abstract
⺠2-Hydroxyoleic acid (2OHOA) caused a dramatic fatty acid remodeling in tumor cells. ⺠After 72 h treatment, 2OHOA accounted for 15% of total fatty acids in phospholipids. ⺠SCD1 inhibition and 2OHOA incorporation accounted for the decrease in oleic acid. ⺠2OHOA decreased membrane global order but increased the packing of ordered domains. ⺠These findings provide a new insight into the 2OHOA antitumor mechanism of action.
Keywords
stearoyl-CoA desaturase-1TAGmembrane lipid therapyhigh performance TLCt-PnA2OHOADPHSCD1MLVstearoyl-CoA desaturaseMUFAHPTLC1,6-diphenyl-1,3,5-hexatrienesphingomyelinsphingolipidsphingomyelin synthasetrans-parinaric acidmonounsaturated fatty acidlarge unilamellar vesicletriacylglyceroldiacylglycerolDAGCancerFAMEphosphatidylinositolphosphatidylcholinephosphatidylethanolaminePhosphatidylserineLUVFatty acid methyl esterMultilamellar vesicleSMS
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Authors
Maria Laura Martin, Gwendolyn Barceló-Coblijn, Rodrigo F.M. de Almeida, Maria Antònia Noguera-Salvà , Silvia Terés, Mónica Higuera, Gerhard Liebisch, Gerd Schmitz, Xavier Busquets, Pablo V. Escribá,