| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797172 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 9 Pages |
Abstract
⺠Effects of 60 ns PEF on [Ca2 +]i were studied by using fast measurements with Fura-2. ⺠NsPEF induced Ca2 + uptake via plasma membrane and Ca2 + efflux from ER. ⺠NsPEF of higher amplitudes triggered amplification of Ca2 + rise via CICR mechanism. ⺠Blocking of IP3R abolished the amplification of Ca2 + response to nsPEF.
Keywords
2-aminoethoxydiphenyl borateplasma membrane Ca2 + ATPaseinositol-1,4,5-trisphosphate receptornsPEFsarco/endoplasmic reticulum Ca2 +-ATPaseNCXFBS2-APBIP3RThapsigarginRyRPMCAEGTADMSO[Ca2 +]iethylene glycol tetraacetic acidElectroporationDissociation constantfetal bovine serumCalcium signalingendoplasmic reticulumSERCASodium–calcium exchangerNanosecond pulsed electric fieldMembrane permeabilizationNanosecond pulseCICRRyanodine receptor
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Authors
Iurii Semenov, Shu Xiao, Andrei G. Pakhomov,