| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797178 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 12 Pages |
Abstract
⺠The short peptaibol trichogin GAIV inserts in the core of the membrane. ⺠Once inserted, it causes a significant thinning of the bilayer. ⺠According to simulations, this is due to its interaction with lipid headgroups. ⺠Its activity increases dramatically in thinner membranes. ⺠It might form barrel-stave channels, like the longer peptaibol alamethicin.
Keywords
HOAt1,1,1,3,3,3-hexafluoroisopropanolSMHTransmembrane peptidesNOCTPeptaibioticsDIEADMFALMFMOCPoPCAMPEDCHFIP1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholineAlamethicinN,N-dimethylformamideN,N-diisopropylethylaminesldα-aminoisobutyric acidNeutron reflectivityScattering length densityMolecular dynamicsMolecular dynamics simulationsAibMembrane thicknessLOLHATUAntimicrobial peptidecarboxyfluorescein
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Authors
S. Bobone, Y. Gerelli, M. De Zotti, G. Bocchinfuso, A. Farrotti, B. Orioni, F. Sebastiani, E. Latter, J. Penfold, R. Senesi, F. Formaggio, A. Palleschi, C. Toniolo, G. Fragneto, L. Stella,