| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797201 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 10 Pages |
Abstract
⺠Substitution of the eleven native Trps in the P-glycoprotein multidrug transporter. ⺠Several Trps at the membrane interface are critical for substrate polyspecificity. ⺠Trps in the coupling helices are important for interdomain communication. ⺠Single Trp mutants can be combined while maintaining drug polyspecificity. ⺠Multi-Trp mutant protein is fully active with reduced intrinsic fluorescence.
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Authors
Douglas J. Swartz, Joachim Weber, Ina L. Urbatsch,