| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797219 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 11 Pages |
Abstract
⺠Cav1.2 and Cav1.3 L-type channels are highly expressed in mammalian adrenal chromaffin cells. ⺠Both isoforms are equally up-modulated by cAMP/PKA and down-modulated by NO/cGMP/PKG. ⺠When opposingly stimulated, PKA and PKG cause up to a factor of ten Ca2 + current variations. ⺠Cav1.3 allows sufficient inward Ca2 + current to surge at sub-threshold potentials. ⺠The Cav1.3 current sets the firing frequency by triggering BK and SK currents.
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Authors
D.H.F. Vandael, S. Mahapatra, C. Calorio, A. Marcantoni, E. Carbone,