| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797225 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 11 Pages |
Abstract
⺠Mutations in the CaV2.1 channel gene cause a rare form of migraine with aura (FHM1). ⺠FHM1 mutations produce gain-of-function of neuronal CaV2.1 channels. ⺠FHM1 mutations enhance cortical excitatory transmission but do not affect inhibitory transmission. ⺠FHM1 mutations facilitate cortical spreading depression. ⺠FHM1 mutations enhance CGRP release at the trigeminal ganglion but not at the dura.
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Authors
Daniela Pietrobon,