| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797230 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 8 Pages |
Abstract
⺠Investigation of the binding of SEPT2 to PtdIns(4,5)P2 and DPPC, using the Langmuir monolayer, DSC and PM-IRRAS techniques ⺠SEPT2 interacts with PtdIns(4,5)P2, remaining incorporated in the monolayer and with its secondary structure preserved. ⺠The binding to DPPC could trigger SEPT2 assembly into amyloid fibrils. ⺠SEPT2 in amyloid filament conformation no longer interacts with PtdIns(4,5)P2 in the Langmuir monolayer.
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Authors
Julio C.P. Damalio, Thatyane M. Nobre, Jose Luiz Lopes, Osvaldo N. Jr., Ana Paula U. Araújo,