| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797232 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2013 | 14 Pages |
Abstract
⺠RW16 is a CPP with reported activity on cancer cell mobility and proliferation. ⺠RW16 interaction with membranes mimicking healthy and cancer cells was investigated. ⺠Zwitterionic lipids mimic healthy cells and anionic lipid cancer cells. ⺠RW16 oligomerization occurs and affects the interaction with membranes. ⺠RW16 induced stronger association and perturbation of anionic membranes.
Keywords
DLSdimyristoyl phosphatidylglyceroldimyristoyl phosphatidylcholineDMPGDOPGDOPCDOPSMLVdMPCGUVDPPCITCMICCPPDSCSARAMPCholarge unilamellar vesicleChinese Hamster OvaryMinimal inhibitory concentrationdioleoyl phosphatidylserineDioleoyl phosphatidylcholineDioleoyl phosphatidylethanolaminedipalmitoyl phosphatidylcholineStructure–activity relationshipcircular dichroismGiant unilamellar vesiclephosphatidylcholinephosphatidylglycerolphosphatidylethanolaminePhosphatidylserineAnticancer activityLUVMultilamellar vesicleDynamic Light Scatteringanti-microbial peptidecell penetrating peptideCell-penetrating peptideDOPEAPAIsothermal titration calorimetryDifferential scanning calorimetry
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Authors
Marie-Lise Jobin, Pierre Bonnafous, Hamza Temsamani, François Dole, Axelle Grélard, Erick J. Dufourc, Isabel D. Alves,