| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797251 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 9 Pages |
Abstract
⺠Phospholipid hydroperoxides fragment to truncated phospholipids. ⺠Truncated phospholipids activate the external PAF receptor, and after internalization activate PPARγ or depolarize mitochondria to initiate apoptosis. ⺠Cytokine signaling creates internal truncated phospholipids that are required mediators of cytokine-induced apoptosis. ⺠PAF acetylhydrolases specifically hydrolyze truncated phospholipids, protecting cells from oxidative death.
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Authors
Thomas M. McIntyre,