| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797252 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 11 Pages |
Abstract
⺠Phospholipid peroxidation results in the formation of oxidation-specific epitopes. ⺠Oxidation-specific epitopes are recognized by soluble and cellular pattern recognition receptors. ⺠Recognition by these receptors promotes the clearance of biological waste. ⺠This innate defense is challenged by increased oxidative stress, such as in chronic inflammation.
Keywords
CFHRcarboxyethylpyrroleMDAPOVPC4-HNE4-hydroxynonenalcpsoxidation-specific epitopeoxLDLRAGMFG-E8CFHCHDMAAAMDBSAOxidized LDLCEPbovine serum albuminNatural antibodiesApoeapolipoprotein Epolyunsaturated fatty acid(s)damage-associated molecular patterncoronary heart diseaseComplement factor HToll-like receptorhigh-mobility group box 1Apoptosisage-related macular degenerationphosphatidylethanolaminephosphocholineLow-density lipoproteinLDLmalondialdehydeLipid peroxidationHeat shock protein(s)C-reactive proteinCRPCapsular polysacchariderecombinase activating geneCardiolipinpattern recognition receptor
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Authors
David Weismann, Christoph J. Binder,