| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10797263 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2012 | 10 Pages |
Abstract
⺠We studied AChR function inhibition by monounsaturated free fatty acids (FFA). ⺠Fluorescence spectroscopy and patch-clamp techniques were used. ⺠AChR function was inhibited by only two of the FFAs studied. ⺠Double bond position in FFAs was directly related to AChR inhibition.
Keywords
AChRNon-competitive antagonistsN-(1-pyrenyl)maleimidePOPACRVNCADPHPoPCFFAsCHOLCARB1,6-diphenyl-1,3,5-hexatrieneAChAcetylcholineFree fatty acidsaturated free fatty acidsFree fatty acidsElectrophysiologyFRETCrystal violetLipid–protein interactiontransmembraneFluorescence spectroscopygeneralized polarizationCarbamylcholinecholesterolnicotinic acetylcholine receptor
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Authors
Vanesa L. Perillo, Gaspar A. Fernández-Nievas, Ana S. Vallés, Francisco J. Barrantes, Silvia S. Antollini,